Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel molecular biomarkers associated with Taxane-induced toxicities in women with breast cancer from the Brazilian Amazon.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Apr 2026

Costa Marta Solange Camarinha Ramos, da Costa Ana Caroline Alves, Pereira Esdras Edgar Batista, da Veiga Borges Leal Diana Feio, Modesto Antônio André Conde, da Silva Menezes Elisa, de Cássia Calderaro Coelho Rita, Dos Santos Sidney Emanuel Batista, Fernandes Marianne Rodrigues, Dos Santos Ney Pereira Carneiro

Abstract excerpt

INTRODUCTION: Taxanes are drugs commonly used in the treatment of breast cancer. Despite their proven therapeutic efficacy, they can induce severe toxicities, which can be investigated by pharmacogenomics. In this context, the aim of this study was to investigate 26 molecular biomarkers in 17 pharmacogenes (CYP2C8, ABCB1, CYP1A1, CYP1B1, CYP19A1, CYP3A5, ERCC1, ERBB2, VEGFA, ERCC2, MDM2, MTHFR, RAD51, SOD2, TP53,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Agents

Share to Biomarkers, Tumor

Share to Brazil

Share to Breast Neoplasms

Share to Docetaxel

Share to Paclitaxel

Share to Taxoids

Source

Identifiers

PMID: 41175304
DOI: 10.1007/s12094-025-04084-9

Genes

XRCC1
CYP19A1
CYP1A1
CYP3A5
ERCC1
ERCC2
MTHFR
VEGFA
ABCB1
CYP1B1
CYP2C8
ERBB2
MDM2
RAD51
SOD2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel molecular biomarkers associated with Taxane-induced toxicities in women with breast cancer from the Brazilian Amazon.PMID 41175304Read ↗

Are pharmacogenomic biomarkers an effective tool to predict taxane toxicity and outcome in breast cancer patients? Literature review.Semantic proximity Read ↗

SNPs and taxane toxicity in breast cancer patients.Semantic proximity Read ↗

Genetic polymorphisms and paclitaxel- or docetaxel-induced toxicities: A systematic review.Semantic proximity Read ↗

Pharmacogenetics of taxane-induced neurotoxicity in breast cancer: Systematic review and meta-analysis.Semantic proximity Read ↗

Pharmacogenetic Approach to Toxicity in Breast Cancer Patients Treated with Taxanes.Semantic proximity Read ↗

Toxicity and Pharmacogenomic Biomarkers in Breast Cancer ChemotherapySemantic proximity Read ↗

Association of CYP1B1 with hypersensitivity induced by taxane therapy in breast cancer patients.Semantic proximity Read ↗

Pharmacogenetics of toxicity of 5-fluorouracil, doxorubicin and cyclophosphamide chemotherapy in breast cancer patientsSemantic proximity Read ↗

CYP2C8 rs11572080 and CYP3A4 rs2740574 risk genotypes in paclitaxel-treated premenopausal breast cancer patients.Semantic proximity Read ↗

Polymorphism of <em>CYP3A4</em> and <em>ABCB1</em> genes increase the risk of neuropathy in breast cancer patients treated with paclitaxel and docetaxelSemantic proximity Read ↗

Pharmacogenomics of anthracycline-cyclophosphamide-taxane chemotherapy: an influence of CYP polymorphisms and BMI on breast cancer treatment outcomes.Semantic proximity Read ↗

Single nucleotide polymorphisms to predict taxanes toxicities and effectiveness in cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.