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Article

Genetic polymorphisms and paclitaxel- or docetaxel-induced toxicities: A systematic review.

Cancer treatment reviews - 1 Dec 2015

Frederiks C N, Lam S W, Guchelaar H J, Boven E

Abstract excerpt

BACKGROUND: Taxanes, including paclitaxel and docetaxel, are indispensable for treatment of cancer. Development of toxicity frequently necessitates dose reduction or discontinuation of therapy, despite clinical response. OBJECTIVE: Pharmacogenetic studies were reviewed for identification of genetic variants possibly underlying individual susceptibility to adverse events. METHOD: We conducted a systematic search...

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Source

Identifiers

PMID: 26585358
DOI: 10.1016/j.ctrv.2015.10.010

Genes

ABCB1
EPHA5
EPHA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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