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Article

Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.

Experimental neurology - 1 Mar 2007

Miller Renee M, Kiser Gretchen L, Kaysser-Kranich Tamma, Casaceli Cindy, Colla Emanuela, Lee Michael K, Palaniappan Chockalingham, Federoff Howard J

Abstract excerpt

The pathophysiological processes that cause Parkinson's disease (PD) affect dopamine neurons residing in the substantia nigra with devastating consequences for normal movement. One important gene involved in both familial and sporadic PD is alpha-synuclein. We have generated three strains of alpha-synuclein transgenic mice to study the pathologic consequences of the targeted expression of mutant or wild-type...

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PMID: 17254569
DOI: 10.1016/j.expneurol.2006.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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