Article
Multi-omics integration combined with multi-source weighted analysis identifies a key microRNA combination that reverses α-synuclein aggregation and pathological phenotypes in Parkinson's disease.
International journal of biological macromolecules - 1 Sept 2026
Wang Guodong, Huang Caihong, Luo Xinxin, Pan Jinmiao, Pan Siyao, Xu Aihao, Liu Quanhui, Chen Jianwei, Sun Longfei, Duan Jiawen, Huang Ben
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by pathological aggregation of α-synuclein and selective loss of dopaminergic neurons. The molecular mechanisms involving microRNA regulation of protein homeostasis remain incompletely understood. METHODS: We integrated single cell RNA-seq, miRNA-seq, bulk RNA-seq, weighted gene co-expression network analysis (WGCNA),...
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