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Article

BRAF mutation predicts for poor outcomes after metastasectomy in patients with metastatic colorectal cancer.

Cancer - 1 Aug 2014

Yaeger Rona, Cercek Andrea, Chou Joanne F, Sylvester Brooke E, Kemeny Nancy E, Hechtman Jaclyn F, Ladanyi Marc, Rosen Neal, Weiser Martin R, Capanu Marinela, Solit David B, D'Angelica Michael I, Vakiani Efsevia, Saltz Leonard B

Abstract excerpt

BACKGROUND: BRAF mutations occur in 5% to 11% of patients with metastatic colorectal cancer (mCRC) and have been associated with poor prognosis. The current study was undertaken to determine the clinicopathologic characteristics, PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) mutation frequency, and outcomes after metastasectomy in patients with BRAF-mutant mCRC. METHODS: Data...

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Source

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Identifiers

PMID: 24737664
DOI: 10.1002/cncr.28729
PMCID: PMC4928876

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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