Article
CCR4 frameshift mutation identifies a distinct group of adult T cell leukaemia/lymphoma with poor prognosis.
The Journal of pathology - 1 Apr 2016
Yoshida Noriaki, Miyoshi Hiroaki, Kato Takeharu, Sakata-Yanagimoto Mamiko, Niino Daisuke, Taniguchi Hiroaki, Moriuchi Yukiyoshi, Miyahara Masaharu, Kurita Daisuke, Sasaki Yuya, Shimono Joji, Kawamoto Keisuke, Utsunomiya Atae, Imaizumi Yoshitaka, Seto Masao, Ohshima Koichi
Abstract excerpt
Adult T cell leukaemia/lymphoma (ATLL) is an intractable T cell neoplasm caused by human T cell leukaemia virus type 1. Next-generation sequencing-based comprehensive mutation studies have revealed recurrent somatic CCR4 mutations in ATLL, although clinicopathological findings associated with CCR4 mutations remain to be delineated. In the current study, 184 cases of peripheral T cell lymphoma, including 113 cases...
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