Article
Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).
Blood - 21 Sept 2017
Park Joonhee, Yang Jingyi, Wenzel Alexander T, Ramachandran Akshaya, Lee Wung J, Daniels Jay C, Kim Juhyun, Martinez-Escala Estela, Amankulor Nduka, Pro Barbara, Guitart Joan, Mendillo Marc L, Savas Jeffrey N, Boggon Titus J, Choi Jaehyuk
Abstract excerpt
Cutaneous T-cell lymphoma (CTCL) is an incurable non-Hodgkin lymphoma of the skin-homing T cell. In early-stage disease, lesions are limited to the skin, but in later-stage disease, the tumor cells can escape into the blood, the lymph nodes, and at times the visceral organs. To clarify the genomic basis of CTCL, we performed genomic analysis of 220 CTCLs. Our analyses identify 55 putative driver genes, including...
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