Article
cDNA-Based Mutation Screening Using a Combination of High-Resolution Melting Curve and Fragment Analysis Facilitates Efficient CCR4 Mutation Analysis in Adult T-Cell Leukemia/Lymphoma.
American journal of clinical pathology - 7 Jul 2020
Mizuta Shumpei, Yamane Noriko, Mononobe Saya, Komai Takao, Koba Yusuke, Kawata Takahito, Ukyo Naoya, Tamekane Akira, Watanabe Mitsumasa
Abstract excerpt
OBJECTIVES: C-C chemokine receptor type 4 (CCR4) proteins are expressed on the neoplastic cells of adult T-cell leukemia/lymphoma (ATLL). As the mutation status of CCR4 gene is reported to correlate with significant clinical information such as prognosis and response to mogamulizumab, we aimed to establish a screening method that is suitable for clinical laboratory tests. METHODS: In 34 patients with ATLL, CCR4...
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