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Article

Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen.

Journal of molecular biology - 15 Jan 2010

Cai Le, Fritz Dillon, Stefanovic Lela, Stefanovic Branko

Abstract excerpt

Type I collagen is the most abundant protein in the human body, produced by folding of two alpha1(I) polypeptides and one alpha2(I) polypeptide into the triple helix. A conserved stem-loop structure is found in the 5' untranslated region of collagen mRNAs, encompassing the translation start codon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19917293
DOI: 10.1016/j.jmb.2009.11.020
PMCID: PMC2826804

Genes

LARP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19917293-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen.PMID 19917293Read ↗

Characterization of binding of LARP6 to the 5' stem-loop of collagen mRNAs: implications for synthesis of type I collagen.Semantic proximity Read ↗

Characterization of sequence specific binding of LARP6 to the 5’ stem-loop of type I collagen mRNAs and implications for rational design of antifibrotic drugsSemantic proximity Read ↗

Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Regulates Translation of Type I Collagen mRNAsSemantic proximity Read ↗

Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA.Semantic proximity Read ↗

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Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.Semantic proximity Read ↗

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