Article
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
Nature genetics - 1 Aug 2013
Bønnelykke Klaus, Matheson Melanie C, Pers Tune H, Granell Raquel, Strachan David P, Alves Alexessander Couto, Linneberg Allan, Curtin John A, Warrington Nicole M, Standl Marie, Kerkhof Marjan, Jonsdottir Ingileif, Bukvic Blazenka K, Kaakinen Marika, Sleimann Patrick, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Schramm Katharina, Baltic Svetlana, Kreiner-Møller Eskil, Simpson Angela, St Pourcain Beate, Coin Lachlan, Hui Jennie, Walters Eugene H, Tiesler Carla M T, Duffy David L, Jones Graham, Ring Susan M, McArdle Wendy L, Price Loren, Robertson Colin F, Pekkanen Juha, Tang Clara S, Thiering Elisabeth, Montgomery Grant W, Hartikainen Anna-Liisa, Dharmage Shyamali C, Husemoen Lise L, Herder Christian, Kemp John P, Elliot Paul, James Alan, Waldenberger Melanie, Abramson Michael J, Fairfax Benjamin P, Knight Julian C, Gupta Ramneek, Thompson Philip J, Holt Patrick, Sly Peter, Hirschhorn Joel N, Blekic Mario, Weidinger Stephan, Hakonarsson Hakon, Stefansson Kari, Heinrich Joachim, Postma Dirkje S, Custovic Adnan, Pennell Craig E, Jarvelin Marjo-Riitta, Koppelman Gerard H, Timpson Nicholas, Ferreira Manuel A, Bisgaard Hans, Henderson A John
Abstract excerpt
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of...
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