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Article

Genetic susceptibility to depressive symptoms in middle-aged to older Americans: time-varying effects and effect modification by early psychosocial factors.

Social psychiatry and psychiatric epidemiology - 1 Jun 2026

Wilding Hannah E, Dyer Walter G, Sutara Brianna, Lee Sung-Ha, Linden-Carmichael Ashley N, Lanza Stephanie T, Lee Harold H

Abstract excerpt

PURPOSE: We examined age-varying genetic influences on depression across young adulthood to older adulthood and the moderating role of early psychosocial factors. METHODS: Data are from the Health and Retirement Study (HRS) with 6,977 European Americans (57% women) from 2006 to 2016 (M age 62.4 ± 14.3, range 26-101 years in 2006). The polygenic score (PGS) for major depression was operationalized as a binary...

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PMID: 40885866
DOI: 10.1007/s00127-025-02987-0
PMCID: PMC13008129

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