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Article

Genetic susceptibility, inflammation and specific types of depressive symptoms: evidence from the English Longitudinal Study of Ageing.

Translational psychiatry - 12 May 2020

Frank Philipp, Ajnakina Olesya, Steptoe Andrew, Cadar Dorina

Abstract excerpt

Genetic susceptibility to depression has been established using polygenic scores, but the underlying mechanisms and the potentially differential effects of polygenic scores on specific types of depressive symptoms remain unknown. This study examined whether systemic low-grade inflammation mediated the association between polygenic scores for depressive symptomatology (DS-PGS) and subsequent somatic versus...

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Identifiers

PMID: 32398645
DOI: 10.1038/s41398-020-0815-9
PMCID: PMC7217832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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