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Article

Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions.

Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Dec 2015

Kato Taku, Kawahito Hiroyuki, Kishida Sou, Irie Daisuke, Wakana Noriyuki, Kikai Masakazu, Takata Hiroki, Ogata Takehiro, Ueyama Tomomi, Matoba Satoaki, Yamada Hiroyuki

Abstract excerpt

BACKGROUND: Bone marrow (BM) Angiotensin II (Ang II) type 1 (AT1) receptor plays a crucial role in atherosclerosis development; however, the effect of BM Ang II type 2 (AT2) receptor on atherogenesis remains undefined. METHODS AND RESULTS: We generated BM chimera apoE-deficient (apoE(-/-)) mice whose BM cells were repopulated with AT2-deficient (Agtr2(-/-)) or wild-type (Agtr2(+/+)) cells. After 2 months of a...

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Share to ATP Binding Cassette Transporter 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver X Receptors

Share to Macrophages, Peritoneal

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Share to Receptor, Angiotensin, Type 2

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Source

Identifiers

PMID: 25487979
DOI: 10.1177/1470320314561138

Genes

ABCA1
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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