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Article

Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2011

Yamamoto Suguru, Yancey Patricia G, Zuo Yiqin, Ma Li-Jun, Kaseda Ryohei, Fogo Agnes B, Ichikawa Iekuni, Linton MacRae F, Fazio Sergio, Kon Valentina

Abstract excerpt

OBJECTIVE: Angiotensin II is a major determinant of atherosclerosis. Although macrophages are the most abundant cells in atherosclerotic plaques and express angiotensin II type 1 receptor (AT1), the pathophysiologic role of macrophage AT1 in atherogenesis remains uncertain. We examined the contribution of macrophage AT1 to accelerated atherosclerosis in an angiotensin II-responsive setting induced by...

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Source

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Identifiers

PMID: 21979434
DOI: 10.1161/ATVBAHA.111.237198
PMCID: PMC3227118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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