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Article

A novel crosstalk between BRCA1 and poly (ADP-ribose) polymerase 1 in breast cancer.

Cell cycle (Georgetown, Tex.) - 1 Jan 2014

Li Da, Bi Fang-Fang, Chen Na-Na, Cao Ji-Min, Sun Wu-Ping, Zhou Yi-Ming, Li Chun-Yan, Yang Qing

Abstract excerpt

BRCA mutations are the main known hereditary factor for breast cancer. Notably, poly (ADP-ribose) polymerase 1 (PARP1) expression status plays a critical role in breast cancer progression and the clinical development of PARP1 inhibitors to treat BRCA-mutated breast cancer has advanced rapidly. However, dynamic crosstalk between BRCA1 and PARP1 remains largely unknown. Here, we showed that: (i) BRCA1 inactivation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25485588
DOI: 10.4161/15384101.2014.956507
PMCID: PMC4613991

Genes

PARP1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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