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Article

PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs

8 Oct 2017

Abstract excerpt

Poly (ADP-ribose) polymerase 1 (PARP1), the best-studied isoform of the nuclear enzyme PARP family, plays a pivotal role in cellular biological processes, such as DNA repair, gene transcription, and so on. PARP1 has been found to be overexpressed in various carcinomas. These all indicate the clinical potential of PARP1 as a therapeutic target of human malignancies. Additionally, multiple preclinical research...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28991194
DOI: 10.3390/ijms18102111

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