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Article

Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C.

Journal of bacteriology - 1 Apr 2008

Kazakov Teymur, Vondenhoff Gaston H, Datsenko Kirill A, Novikova Maria, Metlitskaya Anastasia, Wanner Barry L, Severinov Konstantin

Abstract excerpt

The heptapeptide-nucleotide microcin C (McC) targets aspartyl-tRNA synthetase. Upon its entry into a susceptible cell, McC is processed to release a nonhydrolyzable aspartyl-adenylate that inhibits aspartyl-tRNA synthetase, leading to the cessation of translation and cell growth. Here, we surveyed Escherichia coli cells with singly, doubly, and triply disrupted broad-specificity peptidase genes to show that any...

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Identifiers

PMID: 18223070
DOI: 10.1128/JB.01956-07
PMCID: PMC2293190

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Source receipt: pubmed, retrieved 7 Sept 2026.

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