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Article

Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic.

Journal of biochemistry - 1 Feb 2006

Kim Yong Man, Lee Mi Hyang, Piao Tae Gwang, Lee John Wha, Kim Jong Ho, Lee SungGa, Choi Kyung Min, Jiang Jing Hua, Kim Tae Ue, Park Hyun

Abstract excerpt

Prodomain processing of the four food vacuole plasmepsins (PMs), the malarial aspartic proteases, is prerequisite for their activity on hemoglobin degradation of the parasite Plasmodium falciparum. Although previous studies have suggested the involvement of a calpain-like PM convertase in the processing of PMs, the underlying mechanism of their processing remains to be clarified. Here, to investigate the...

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PMID: 16452306
DOI: 10.1093/jb/mvj018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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