Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of PAX4 reduces glucagon expression in differentiating hESCs

1 Mar 2014

Abstract excerpt

Human embryonic stem cells (hESCs) are pluripotent and capable of generating new β-cells, but current in vitro differentiation protocols generally fail to produce mature, glucose-responsive, unihormonal β-cells. Instead, these methods tend to produce immature polyhormonal endocrine cells which mature in vivo into glucagon-positive α-cells. PAX4 is an established transcription factor in β-cell development and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pancreatic function and diabetes
Share to Pluripotent Stem Cells Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25483960
DOI: 10.4161/isl.29236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of PAX4 reduces glucagon expression in differentiating hESCsPMID 25483960Read ↗

Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell LineSemantic proximity Read ↗

PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes TreatmentSemantic proximity Read ↗

Tracking insulin- and glucagon-expressing bihormonal cells during differentiation using an <i>INSULIN</i> and <i>GLUCAGON</i> double reporter human embryonic stem cell lineSemantic proximity Read ↗

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1Semantic proximity Read ↗

Pancreatic islet differentiation of human embryonic stem cells by microRNA overexpressionSemantic proximity Read ↗

PAX4 Enhances Beta-Cell Differentiation of Human Embryonic Stem CellsSemantic proximity Read ↗

Pax4 in Health and DiabetesSemantic proximity Read ↗

Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell LineSemantic proximity Read ↗

Directed Differentiation of Human Embryonic Stem Cells into the Pancreatic Endocrine LineageSemantic proximity Read ↗

<i>glucagon</i> is essential for alpha cell transdifferentiation and beta cell neogenesisSemantic proximity Read ↗

The Role of ARX in Human Pancreatic Endocrine SpecificationSemantic proximity Read ↗

Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.