Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PAX4 Enhances Beta-Cell Differentiation of Human Embryonic Stem Cells

12 Mar 2008

Abstract excerpt

BACKGROUND: Human embryonic stem cells (HESC) readily differentiate into an apparently haphazard array of cell types, corresponding to all three germ layers, when their culture conditions are altered, for example by growth in suspension as aggregates known as embryoid bodies (EBs). However, this diversity of differentiation means that the efficiency of producing any one particular cell type is inevitably low....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Pancreatic function and diabetes
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18335054
DOI: 10.1371/journal.pone.0001783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PAX4 Enhances Beta-Cell Differentiation of Human Embryonic Stem CellsPMID 18335054Read ↗

From iPSCs to Pancreatic β Cells: Unveiling Molecular Pathways and Enhancements With Vitamin C and Retinoic Acid in Diabetes ResearchSemantic proximity Read ↗

Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation.Semantic proximity Read ↗

Insulin-producing cells.Semantic proximity Read ↗

Biphasic Induction of Pdx1 in Mouse and Human Embryonic Stem Cells Can Mimic Development of Pancreatic β-CellsSemantic proximity Read ↗

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic IsletSemantic proximity Read ↗

PAX4 loss of function alters human endocrine cell development and influences diabetes riskSemantic proximity Read ↗

Overexpression of PAX4 reduces glucagon expression in differentiating hESCsSemantic proximity Read ↗

Pax4 in Health and DiabetesSemantic proximity Read ↗

Generation of Insulin-Producing Islet-Like Clusters from Human Embryonic Stem CellsSemantic proximity Read ↗

Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factorsSemantic proximity Read ↗

[Transcription Factor PAX4: Role in Differentiation of Insulin- Producing β Cells during Pancreas Development and Association with Diabetes].Semantic proximity Read ↗

Pathways governing development of stem cell‐derived pancreatic β cells: lessons from embryogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.