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Regulation of EMT by TGFβ in cancer

28 Feb 2012

Abstract excerpt

Transforming growth factor-β (TGFβ) suppresses tumor formation since it inhibits cell growth and promotes apoptosis. However, in advanced cancers TGFβ elicits tumor promoting effects through its ability to induce epithelial-mesenchymal transition (EMT) which enhances invasiveness and metastasis; in addition, TGFβ exerts tumor promoting effects on non-malignant cells of the tumor, including suppression of immune...

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PMID: 22710176
DOI: 10.1016/j.febslet.2012.02.037

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