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Article

Shifting epigenetic contexts influence regulatory variation and disease risk.

Aging - 16 Jun 2021

Richard Daniel, Capellini Terence D

Abstract excerpt

Epigenetic shifts are a hallmark of aging that impact transcriptional networks at regulatory level. These shifts may modify the effects of genetic regulatory variants during aging and contribute to disease pathomechanism. However, these shifts occur on the backdrop of epigenetic changes experienced throughout an individual's development into adulthood; thus, the phenotypic, and ultimately fitness, effects of...

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Identifiers

PMID: 34138751
DOI: 10.18632/aging.203194
PMCID: PMC8266365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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