Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of heme oxygenase-1 with hemin reduces obesity-induced adipose tissue inflammation via adipose macrophage phenotype switching.

Mediators of inflammation - 1 Jan 2014

Tu Thai Hien, Joe Yeonsoo, Choi Hye-Seon, Chung Hun Taeg, Yu Rina

Abstract excerpt

Adipose macrophages with the anti-inflammatory M2 phenotype protect against obesity-induced inflammation and insulin resistance. Heme oxygenase-1 (HO-1), which elicits antioxidant and anti-inflammatory activity, modulates macrophage phenotypes and thus is implicated in various inflammatory diseases. Here, we demonstrate that the HO-1 inducer, hemin, protects against obesity-induced adipose inflammation by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Adipocytes
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Coculture Techniques

Share to Enzyme Induction

Share to Heme Oxygenase-1

Share to Inflammation Mediators

Source

Open in PubMed Open full text

Identifiers

PMID: 25477711
DOI: 10.1155/2014/290708
PMCID: PMC4244973

Genes

STAT6
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of heme oxygenase-1 with hemin reduces obesity-induced adipose tissue inflammation via adipose macrophage phenotype switching.PMID 25477711Read ↗

The heme oxygenase system selectively enhances the anti-inflammatory macrophage-M2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in Zucker diabetic fatty rats.Semantic proximity Read ↗

Macrophages, meta-inflammation, and immuno-metabolism.Semantic proximity Read ↗

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.Semantic proximity Read ↗

Phenotypic Switch of Adipose Tissue Macrophages as a Target to Reduce Obesity-Associated Metabolic RiskSemantic proximity Read ↗

The heme oxygenase system selectively suppresses the proinflammatory macrophage m1 phenotype and potentiates insulin signaling in spontaneously hypertensive rats.Semantic proximity Read ↗

M1/M2 macrophage polarization in human obese adipose tissue.Semantic proximity Read ↗

Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states.Semantic proximity Read ↗

IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesitySemantic proximity Read ↗

P311 Curtails Inflammation Through M2-Type Polarization of Macrophages and Potentially via Gut Microbiome ModulationSemantic proximity Read ↗

Adipose-Derived Stem Cells from Obese Donors Polarize Macrophages and Microglia toward a Pro-Inflammatory Phenotype.Semantic proximity Read ↗

Carbon Monoxide Regulates Macrophage Differentiation and Polarization toward the M2 Phenotype through Upregulation of Heme Oxygenase 1.Semantic proximity Read ↗

Human adipose tissue macrophages are enhanced but changed to an anti-inflammatory profile in obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.