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Adipose-Derived Stem Cells from Obese Donors Polarize Macrophages and Microglia toward a Pro-Inflammatory Phenotype.

Cells - 25 Dec 2020

Harrison Mark A A, Wise Rachel M, Benjamin Brooke P, Hochreiner Emily M, Mohiuddin Omair A, Bunnell Bruce A

Abstract excerpt

Macrophages and microglia represent the primary phagocytes and first line of defense in the peripheral and central immune systems. They activate and polarize into a spectrum of pro- and anti-inflammatory phenotypes in response to various stimuli. This activation is tightly regulated to balance the appropriate immune response with tissue repair and homeostasis. Disruption of this balance results in inflammatory...

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Identifiers

PMID: 33375695
DOI: 10.3390/cells10010026
PMCID: PMC7823699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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