M1/M2 macrophage polarization in human obese adipose tissue.

doi:10.5507/bp.2018.015

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Article

M1/M2 macrophage polarization in human obese adipose tissue.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia - 1 Jun 2018

Chylikova Jaroslava, Dvorackova Jana, Tauber Zdenek, Kamarad Vojtech

Abstract excerpt

Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-6 and MCP-1) and thus contribute to the development of...

Topics

Adipose Tissue
Chemokine CCL2
Humans
Hypoxia
Insulin Resistance
Interleukin-6
Macrophages
Obesity
Phenotype
Tumor Necrosis Factor-alpha

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Open in PubMed

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PMID: 29765169
DOI: 10.5507/bp.2018.015

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