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Article

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2015

Shih Diana M, Yu Janet M, Vergnes Laurent, Dali-Youcef Nassim, Champion Matthew D, Devarajan Asokan, Zhang Peixiang, Castellani Lawrence W, Brindley David N, Jamey Carole, Auwerx Johan, Reddy Srinivasa T, Ford David A, Reue Karen, Lusis Aldons J

Abstract excerpt

We report the engineering and characterization of paraoxonase-3 knockout mice (Pon3KO). The mice were generally healthy but exhibited quantitative alterations in bile acid metabolism and a 37% increased body weight compared to the wild-type mice on a high fat diet. PON3 was enriched in the mitoch...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25477283
DOI: 10.1096/fj.14-260570
PMCID: PMC4396607

Genes

PON3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25477283-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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