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Article

Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?

Journal of molecular biology - 3 Sept 2021

Walker Caitlin, Wang Yingjie, Olivieri Cristina, V S Manu, Gao Jiali, Bernlohr David A, Calebiro Davide, Taylor Susan S, Veglia Gianluigi

Abstract excerpt

Somatic mutations in the PRKACA gene encoding the catalytic α subunit of protein kinase A (PKA-C) are responsible for cortisol-producing adrenocortical adenomas. These benign neoplasms contribute to the development of Cushing's syndrome. The majority of these mutations occur at the interface between the two lobes of PKA-C and interfere with the enzyme's ability to recognize substrates and regulatory (R) subunits,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34224748
DOI: 10.1016/j.jmb.2021.167123
PMCID: PMC8409435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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