Article
Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease.
PLoS genetics - 1 Dec 2014
Johnson Michelle D, Mueller Michael, Adamowicz-Brice Martyna, Collins Melissa J, Gellert Pascal, Maratou Klio, Srivastava Prashant K, Rotival Maxime, Butt Shahena, Game Laurence, Atanur Santosh S, Silver Nicholas, Norsworthy Penny J, Langley Sarah R, Petretto Enrico, Pravenec Michal, Aitman Timothy J
Abstract excerpt
Epigenetic marks such as cytosine methylation are important determinants of cellular and whole-body phenotypes. However, the extent of, and reasons for inter-individual differences in cytosine methylation, and their association with phenotypic variation are poorly characterised. Here we present the first genome-wide study of cytosine methylation at single-nucleotide resolution in an animal model of human disease....
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