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Article

Lattice-based model of ductal carcinoma in situ suggests rules for breast cancer progression to an invasive state.

PLoS computational biology - 1 Dec 2014

Boghaert Eline, Radisky Derek C, Nelson Celeste M

Abstract excerpt

Ductal carcinoma in situ (DCIS) is a heterogeneous group of non-invasive lesions of the breast that result from abnormal proliferation of mammary epithelial cells. Pathologists characterize DCIS by four tissue morphologies (micropapillary, cribriform, solid, and comedo), but the underlying mechanisms that distinguish the development and progression of these morphologies are not well understood. Here we explored...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25473842
DOI: 10.1371/journal.pcbi.1003997
PMCID: PMC4256017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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