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Article

Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling.

Integrative biology : quantitative biosciences from nano to macro - 1 Apr 2011

Tang Jonathan, Enderling Heiko, Becker-Weimann Sabine, Pham Christopher, Polyzos Aris, Chen Chen-Yi, Costes Sylvain V

Abstract excerpt

We introduce an agent-based model of epithelial cell morphogenesis to explore the complex interplay between apoptosis, proliferation, and polarization. By varying the activity levels of these mechanisms we derived phenotypic transition maps of normal and aberrant morphogenesis. These maps identify homeostatic ranges and morphologic stability conditions. The agent-based model was parameterized and validated using...

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Identifiers

PMID: 21373705
DOI: 10.1039/c0ib00092b
PMCID: PMC4009383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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