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Article

A quantitative theoretical model for the development of malignancy in ductal carcinoma in situ.

Journal of theoretical biology - 21 Feb 2010

Silva Ariosto S, Gatenby Robert A, Gillies Robert J, Yunes Jose Andres

Abstract excerpt

Mathematical models and clinical observations have demonstrated that microenvironmental hypoxia and acidosis are important selection factors during the later stages of the somatic evolution of breast cancer. The consequent promotion of constitutive upregulation of glycolysis and resistance to acid-induced cellular toxicity is hypothesized to be critical for the ability of cancer cells to invade host tissue. In...

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Identifiers

PMID: 19887072
DOI: 10.1016/j.jtbi.2009.10.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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