Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatially Discontinuous Mutation Topographies in Ductal Carcinoma In Situ Reveal Noncompetitive Growth Dynamics.

Cancer research - 15 Dec 2025

Ryser Marc D, Greenwald Matthew A, Monyak Daniel, Sorribes Inmaculada C, King Lorraine, Hall Allison, Geradts Joseph, Weaver Donald L, Mallo Diego, Holloway Shannon T, Wu Ethan, Murgas Kevin A, West Robert B, Grimm Lars J, Maley Carlo C, Marks Jeffrey R, Shibata Darryl, Hwang E Shelley

Abstract excerpt

Preinvasive breast cancer, or ductal carcinoma in situ (DCIS), shares many morphologic and genomic features with invasive breast cancer, yet most DCIS tumors remain indolent over decades. In this study, we performed spatial analyses of somatic mutation patterns in 18 DCIS tumors to infer the underlying growth dynamics. Experimental data combined with mathematical models and Bayesian computation revealed a growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Intraductal, Noninfiltrating

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 41066536
DOI: 10.1158/0008-5472.CAN-24-4415
PMCID: PMC12950944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatially Discontinuous Mutation Topographies in Ductal Carcinoma In Situ Reveal Noncompetitive Growth Dynamics.PMID 41066536Read ↗

Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast DevelopmentSemantic proximity Read ↗

The breast pre-cancer atlas illustrates the molecular and micro-environmental diversity of ductal carcinoma in situSemantic proximity Read ↗

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Complex Genotypic-Phenotypic Relationships Altering Epithelial CompositionSemantic proximity Read ↗

A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progressionSemantic proximity Read ↗

Dedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling studySemantic proximity Read ↗

Progression from ductal carcinoma <i>in situ</i> to invasive breast cancer: RevisitedSemantic proximity Read ↗

Genome evolution in ductal carcinoma in situ: invasion of the clonesSemantic proximity Read ↗

Multi-omic profiling of simultaneous ductal carcinoma in situ and invasive breast cancer.Semantic proximity Read ↗

Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic-Phenotypic Relationships Altering Epithelial Composition.Semantic proximity Read ↗

Genomic Alterations during the In Situ to Invasive Ductal Breast Carcinoma Transition Shaped by the Immune SystemSemantic proximity Read ↗

Evolutionary Measures Show that Recurrence of DCIS is Distinct from Progression to Breast CancerSemantic proximity Read ↗

Tumor microenvironmental determinants of high-risk DCIS progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.