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Article

A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres.

Journal of neuro-oncology - 1 Feb 2015

Borodovsky Alexandra, Meeker Alan K, Kirkness Ewen F, Zhao Qi, Eberhart Charles G, Gallia Gary L, Riggins Gregory J

Abstract excerpt

Mutations in isocitrate dehydrogenase 1 (IDH1) have been found in the vast majority of low grade and progressive infiltrating gliomas and are characterized by the production of 2-hydroxyglutarate from α-ketoglutarate. Recent investigations of malignant gliomas have identified additional genetic and chromosomal abnormalities which cluster with IDH1 mutations into two distinct subgroups. The astrocytic subgroup was...

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Source

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Identifiers

PMID: 25471051
DOI: 10.1007/s11060-014-1672-2
PMCID: PMC4648276

Genes

IDH1
ATRX
CIC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres.PMID 25471051Read ↗

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