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Article

<b>TGF-β induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells</b>

2 Nov 2014

Abstract excerpt

A key step in the process of metastasis is the epithelial-to-mesenchymal transition (EMT). We hypothesized that epigenetic mechanisms play a key role in EMT and to test this hypothesis we analyzed global and gene-specific changes in DNA methylation during TGF-β-induced EMT in ovarian cancer cells. Epigenetic profiling using the Infinium HumanMethylation450 BeadChip (HM450) revealed extensive (P < 0.01)...

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PMID: 25470663
DOI: 10.4161/15592294.2014.971608

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