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Transcriptional and Post-transcriptional Regulation in TGF- -mediated epithelial-mesenchymal transition

23 Apr 2012

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a crucial event in appropriate embryonic development as well as in wound healing, tissue repair and cancer progression in adult tissues. EMT endows cells with migratory and invasive properties, inhibits apoptosis and senescence, contributes to immunosuppression and induces stress resistance and stem cell properties. Many secreted polypeptide factors act in a sequential...

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PMID: 22528665
DOI: 10.1093/jb/mvs040

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