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Article

TGF-β: friend or foe? The role of TGF-β/SMAD signaling in epigenetic silencing of ovarian cancer and its implication in epigenetic therapy

6 Oct 2010

Abstract excerpt

IMPORTANCE OF THE FIELD: The TGF-β signaling pathway plays an important role in regulating numerous cellular processes including growth inhibition of ovarian surface epithelial (OSE) cells. However, epithelial ovarian cancer is refractory to the inhibitory functions of TGF-β, and yet TGF-β induces metastasis or epithelial-mesenchymal transition (EMT) in advanced ovarian cancer. How TGF-β plays a certain role in...

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Share to Epigenetics and DNA Methylation
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PMID: 20925461
DOI: 10.1517/14728222.2010.525353

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