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Article

Transforming growth factor beta 1 induces methylation changes in lung fibroblasts

11 Oct 2019

Abstract excerpt

Idiopathic pulmonary fibrosis is a complex disease of unknown etiology. Environmental factors can affect disease susceptibility via epigenetic effects. Few studies explore global DNA methylation in lung fibroblasts, but none have focused on transforming growth factor beta-1 (TGF-β1) as a potential modifier of the DNA methylome. Here we analyzed changes in methylation and gene transcription in normal and IPF...

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Share to Epigenetics and DNA Methylation
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 31603936
DOI: 10.1371/journal.pone.0223512

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