Article
The Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is associated with type 2 diabetes in Tunisian population.
Diabetes & metabolic syndrome - 1 Jan 2000
Jemaa Zeineb, Kallel Amani, Sleimi Chaker, Mahjoubi Imen, Feki Moncef, Ftouhi Bochra, Slimane Hedia, Jemaa Riadh, Kaabachi Naziha
Abstract excerpt
BACKGROUND AND AIMS: Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a transcriptional co-activator involved in adaptive thermogenesis, skeletal muscle metabolism, fatty acid oxidation, and gluconeogenesis. Several studies have suggested that the common PGC-1α polymorphism Gly482Ser (rs8192678) may be associated with risk of type 2 diabetes (T2D), with conflicting results. The aim of this...
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