Article
Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) gene in Danish subjects with the metabolic syndrome.
Diabetes research and clinical practice - 1 Feb 2005
Ambye Louise, Rasmussen Susanne, Fenger Mogens, Jørgensen Torben, Borch-Johnsen Knut, Madsbad Sten, Urhammer Søren A
Abstract excerpt
The peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) is a novel transcriptional co-activator that holds an important role in lipid and glucose metabolism. PGC-1alpha is a candidate gene for the metabolic syndrome (MS) as well as type 2 diabetes. Recent studies suggested linkage between the chromosomal region of PGC-1alpha and fasting serum insulin levels, and associates a...
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