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Article

Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.

Endocrinology - 1 Feb 2018

Vandenbeek Roxanne, Khan Naveen P, Estall Jennifer L

Abstract excerpt

Peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) is a highly conserved transcriptional coactivator enriched in metabolically active tissues including liver, adipose, pancreas, and muscle. It plays a role in regulating whole body energy metabolism and its deregulation has been implicated in type 2 diabetes (T2D). A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29186342
DOI: 10.1210/en.2017-00872

Genes

PGC

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Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.PMID 29186342Read ↗

A Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene is associated with type 2 diabetes in Caucasians.Semantic proximity Read ↗

Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.Semantic proximity Read ↗

The Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is associated with type 2 diabetes in Tunisian population.Semantic proximity Read ↗

The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.Semantic proximity Read ↗

A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians.Semantic proximity Read ↗

Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus.Semantic proximity Read ↗

Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations.Semantic proximity Read ↗

Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) gene in Danish subjects with the metabolic syndrome.Semantic proximity Read ↗

Common variation at PPARGC1A/B and change in body composition and metabolic traits following preventive interventions: the Diabetes Prevention Program.Semantic proximity Read ↗

Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes.Semantic proximity Read ↗

Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1alpha gene.Semantic proximity Read ↗

A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.Semantic proximity Read ↗

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