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Article

Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness.

Science advances - 30 Jun 2023

Oropeza Elena, Seker Sinem, Carrel Sabrina, Mazumder Aloran, Lozano Daniel, Jimenez Athena, VandenHeuvel Sabrina N, Noltensmeyer Dillon A, Punturi Nindo B, Lei Jonathan T, Lim Bora, Waltz Susan E, Raghavan Shreya A, Bainbridge Matthew N, Haricharan Svasti

Abstract excerpt

Cell cycle dysregulation is prerequisite for cancer formation. However, it is unknown whether the mode of dysregulation affects disease characteristics. Here, we conduct comprehensive analyses of cell cycle checkpoint dysregulation using patient data and experimental investigations. We find that ATM mutation predisposes the diagnosis of primary estrogen receptor (ER)+/human epidermal growth factor (HER)2- cancer...

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Identifiers

PMID: 37390209
DOI: 10.1126/sciadv.adf2860
PMCID: PMC10313178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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