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Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition

14 Nov 2022

Abstract excerpt

Excessive genomic instability coupled with abnormalities in DNA repair pathways induces high levels of 'replication stress' when cancer cells propagate. Rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention towards targeting cell cycle checkpoint kinases (such as ATR, CHK1, WEE1, and others) along the DNA damage response and replicative stress response pathways,...

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PMID: 36373784
DOI: 10.1002/path.6032

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