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Article

Targeting of type I interferon in systemic autoimmune diseases.

Translational research : the journal of laboratory and clinical medicine - 1 Feb 2015

Crow Mary K, Olferiev Mikhail, Kirou Kyriakos A

Abstract excerpt

Increased blood levels of type I interferon (IFN-I) and expression of a broad signature of gene transcripts that reflect induction by IFN-I are observed in many patients with systemic autoimmune diseases, and that pattern is most striking in systemic lupus erythematosus (SLE). Persistent production of IFN-α, the most abundant subtype measured in these patients, is an important feature of the immunopathogenesis of...

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Source

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Identifiers

PMID: 25468480
DOI: 10.1016/j.trsl.2014.10.005
PMCID: PMC4306610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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