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Article

Role of intracellular prostaglandin E₂ in cancer-related phenotypes in PC3 cells.

The international journal of biochemistry & cell biology - 1 Feb 2015

Madrigal-Martínez Antonio, Cazaña Francisco J Lucio, Fernández-Martínez y Ana B

Abstract excerpt

Prostaglandin E2 (PGE2) and hypoxia-inducible factor-1α (HIF-1α) affect many mechanisms that have been shown to play a role in prostate cancer. In PGE2-treated LNCaP cells, up-regulation of HIF-1α requires the internalization of PGE2, which is in sharp contrast with the generally accepted view that PGE2 acts through EP receptors located at the cell membrane. Here we aimed to study in androgen-independent PC3...

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Identifiers

PMID: 25462156
DOI: 10.1016/j.biocel.2014.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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