Article
The EP1 subtype of prostaglandin E2 receptor: role in keratinocyte differentiation and expression in non-melanoma skin cancer.
Prostaglandins, leukotrienes, and essential fatty acids - 1 Oct 2009
Konger R L, Billings S D, Prall N C, Katona T M, Dasilva S C, Kennedy C R J, Badve S, Perkins S M, Lacelle P T
Abstract excerpt
We have previously demonstrated that the EP1 subtype of PGE2 receptor is expressed in the differentiated compartment of normal human epidermis and is coupled to intracellular calcium mobilization. We therefore hypothesized that the EP1 receptor is coupled to keratinocyte differentiation. In in vitro studies, radioligand binding, RT-PCR, immunoblot and receptor agonist-induced second messenger studies demonstrate...
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