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Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zeta.

DNA repair - 1 Dec 2014

Doerfler Lillian, Schmidt Kristina H

Abstract excerpt

Exo1 belongs to the Rad2 family of structure-specific nucleases and possesses 5'-3' exonuclease activity on double-stranded DNA substrates. Exo1 interacts physically with the DNA mismatch repair (MMR) proteins Msh2 and Mlh1 and is involved in the excision of the mispaired nucleotide. Independent of its role in MMR, Exo1 contributes to long-range resection of DNA double-strand break (DSB) ends to facilitate their...

Topics

Amino Acid Transport Systems, Basic
DNA Damage
DNA Mismatch Repair
DNA Repair
DNA-Directed DNA Polymerase
Exodeoxyribonucleases
Hydroxyurea
MutS Homolog 2 Protein
Mutation
Phosphorylation
RecQ Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

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Open in PubMed Open full text

Identifiers

PMID: 25457771
DOI: 10.1016/j.dnarep.2014.10.004
PMCID: PMC4418189

Genes

EXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zeta.PMID 25457771Read ↗

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