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Article

Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016

Schafer Christopher T, Fay Jonathan F, Janz Jay M, Farrens David L

Abstract excerpt

Here, we describe two insights into the role of receptor conformational dynamics during agonist release (all-trans retinal, ATR) from the visual G protein-coupled receptor (GPCR) rhodopsin. First, we show that, after light activation, ATR can continually release and rebind to any receptor remaining in an active-like conformation. As with other GPCRs, we observe that this equilibrium can be shifted by either...

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Identifiers

PMID: 27702898
DOI: 10.1073/pnas.1606347113
PMCID: PMC5081659

Genes

ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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