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Article

Effect of channel mutations on the uptake and release of the retinal ligand in opsin.

Proceedings of the National Academy of Sciences of the United States of America - 3 Apr 2012

Piechnick Ronny, Ritter Eglof, Hildebrand Peter W, Ernst Oliver P, Scheerer Patrick, Hofmann Klaus Peter, Heck Martin

Abstract excerpt

In the retinal binding pocket of rhodopsin, a Schiff base links the retinal ligand covalently to the Lys296 side chain. Light transforms the inverse agonist 11-cis-retinal into the agonist all-trans-retinal, leading to the active Meta II state. Crystal structures of Meta II and the active conformation of the opsin apoprotein revealed two openings of the 7-transmembrane (TM) bundle towards the hydrophobic core of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22431612
DOI: 10.1073/pnas.1117268109
PMCID: PMC3325672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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