Article
Choline kinase β mutant mice exhibit reduced phosphocholine, elevated osteoclast activity, and low bone mass.
The Journal of biological chemistry - 16 Jan 2015
Kular Jasreen, Tickner Jennifer C, Pavlos Nathan J, Viola Helena M, Abel Tamara, Lim Bay Sie, Yang Xiaohong, Chen Honghui, Cook Robert, Hool Livia C, Zheng Ming Hao, Xu Jiake
Abstract excerpt
The maintenance of bone homeostasis requires tight coupling between bone-forming osteoblasts and bone-resorbing osteoclasts. However, the precise molecular mechanism(s) underlying the differentiation and activities of these specialized cells are still largely unknown. Here, we identify choline kinase β (CHKB), a kinase involved in the biosynthesis of phosphatidylcholine, as a novel regulator of bone homeostasis....
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