Article

Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK

2024-03-23

Abstract excerpt

Phospholipase C beta (PLCβ) exerts diverse biological processes, including inflammatory responses and neurogenesis; however, its role in bone cell function is largely unknown. Among the PLCβ isoforms (β1–β4), we found that PLCβ4 was most highly upregulated during osteoclastogenesis. In this study, we used global knockout and osteoclast lineage-specific PLCβ4 conditional knockout ( LysM-PLCβ4 −/− ) mice and demon...

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Literature Corpus work: a8c01d8b-f990-5e2d-ad0c-66abe9a4da6f
DOI: 10.1101/2024.03.19.585823

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